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  UPCOMING EVENTS   Selected Seminar        
     
 
Date: 10 April 2017
Time: 11:00am | Level 3, IMCB Seminar Room 3-46, Proteos
Speaker: Dr. Reinhard Jahn
Title: Membrane fusion in the secretory pathway of eukaryotic cells


Eukaryotic cells are compartmentalized into membrane-enclosed organelles. Most of them are connected with each other by the regulated exchange of transport vesicles that bud from the precursor membrane and are transported to their destination membrane where they dock and fuse. In most (but not all) cases, fusion is carried out by SNAREs that represent an evolutionarily conserved superfamily of small and mostly membrane-anchored proteins. SNAREs are distinguished by a conserved stretch of 60-70 amino acids, termed SNARE-motifs, that are located adjacent to the membrane anchor domain. During fusion, four of such SNARE motifs, each belonging to a different subfamily, align with each other to form a highly stable coiled-coil of α-helices. Complex formation proceeds from the N-terminal end towards the C-terminal membrane anchors, thus pulling the membranes together and initiating fusion (“zipper” hypothesis of SNARE function). The steps of SNARE assembly are controlled by members of conserved protein families such as the SM- and CATCHR-proteins, with additional proteins being involved in regulated exocytosis. In our own work, we have focused on understanding the mechanisms of SNARE assembly and SNARE-induced fusion using structural and biochemical approaches and in-vitro fusion reactions with native and artificial membranes. Furthermore, we have recently extended our work towards SNARE-“mimetics”, including SNARE-like synthetic molecules with artificially designed adhesion domains as well as membrane proteins of bacterial pathogens that are capable of substituting for endogenous SNAREs. We hope to achieve a better understanding of the energy landscape of the fusion pathway, thus shedding more light on a reaction fundamental to all eukaryotic cells.

Biography:
Reinhard Jahn studied biology and chemistry at the Universities of Freiburg and Göttingen (doctorate in 1981). He was postdoctoral fellow at Yale and Rockefeller University (1983-1985), and assistant professor at Rockefeller University (1985-1986). Between 1986 and 1991 he was junior research group leader at the Max Planck Institute of Psychiatry in Munich. 1991 he moved to Yale University as associate/full professor for pharmacology and cell biology and as investigator of the Howard Hughes Medical Institute. In 1997 he became Director at the Max Planck Institute for Biophysical Chemistry. He has obtained several awards including the Leibniz-Prize (2000), the Ernst Jung Prize for Medicine (2006), the Sir Bernhard Katz Award (2008), the Heinrich Wieland Prize (2014) and the Balzan Prize (2016). Eleced Memberships include the European Molecular Biology Organization (EMBO), the German National Academy Leopoldina, the Academia Europaea, and the National Academy of Sciences of the United States.


Host: Prof. Wanjin Hong

 
     

 
 
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