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  UPCOMING EVENTS   Selected Seminar        
Date: 22 May 2017
Time: 11:00am | Level 3, IMCB Seminar Room 3-46, Proteos
Speaker: Dr. Ivan Topisirovic
Title: Coordination of protein synthesis and energy metabolism

mRNA translation (protein synthesis) is one of the most energy consuming processes in the cell. Energy metabolism and protein synthesis are dysregulated in a number of pathological states including cancer. However, how mRNA translation and energy production are coordinated remains underexplored. The mammalian/mechanistic target of rapamycin (mTOR) is a major pathway that regulates mRNA translation. Our recent findings demonstrate that mTOR plays a pivotal role in coordinating protein synthesis and mitochondrial energy production via 4E-BP-dependent perturbations of the translatome. Moreover, we defined 5’ UTR features that dictate differential modes of translation of functionally distinct mTOR-sensitive mRNA. In particular, a subset of mTOR-sensitive mRNAs with short 5’ UTRs, that are enriched in those encoding proteins with mitochondrial functions, appear to exhibit unique mode of translation, inasmuch as they require mRNA 5’ cap binding protein eIF4E, but not eIF4A1 helicase. Implications of these findings on targeting metabolic vulnerabilities of cancer will be discussed.

Ivan Topisirovic obtained M.D. and Ph.D. at the University of Belgrade, Yugoslavia in Dr. Romac’s lab. During his postdoc in Drs. Borden's and Sonenberg's labs, he studied the mechanisms of post-transcriptional regulation of gene expression and mTOR-dependent mRNA translation, respectively. In 2011, he became a Principal Investigator at the Lady Davis Institute, McGill University. Topisirovic published ~ 75 manuscripts in journals such as Genome Res, Cell Metabolism, NRDD and Science. He is a recipient of several awards including Governor General Award for Leukemia Research, CIHR Young Investigator Award and a Honorary Member of the Serbian Society for Molecular Biology. Topisirovic's current research focuses on uncovering the differences between the mechanisms that coordinate translatomes and metabolomes in normal versus cancer cells, with the aim to identify therapeutically exploitable vulnerabilities of neoplasia.

Host: Dr. Ernesto Guccione


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